I have been thinking, as I mentioned above, that whoever opens hubs the fastest will probably be at the biggest disadvantage, so I am going to start discussing strategy just for fun.
My first hub will be at London Heathrow, and I am going to start shorter service at first to only the Largest European Airports. As those routes receive competition, I'll start flying to the US and Asia once I have some more aircraft, and then slowly open hubs. Better off doing a ton of routes from one hub than a few routes from several hubs.