Hm, well here are some questions to consider:
1) "Am I making enough for that route?" (typically over 6-7K is ok in my opinion, though I never started from a super large airport).
2) "Who am I competing with?" If you're not competing with anyone, or have reletivly weak competition, it could be good to cut it (though I imagine that MSP has to be filled with many airlines trying to strike it large). If they're much larger, it might be wise to cut it if it isn't going to make you money in the end of the month (remember, gate costs, maint costs, other costs). Also, don't be afraid to cut the freqs, typically 1 is enough with the current format.