I guess it also depends on long-haul destinations. For me, routes like PIT-LHR/CDG/NRT and even SYD with the 772LR were huge money makers for me, while some other routes not so much. So I think it also depends on the type of your destination (i.e. amount of traffic to anticipate between city pairs).
As for me this round, I just launched PIT-LHR with a DC4, which actually makes a nice buck at 165k Euros. That is only until I gues some Lockheed Constitutions and Super Constellations. They have a range of over 5,300 nm. I should be able to use them on routes like MCO-TLV and the like. I might turn to Boeing for the very long-haul flying. What kind of range do the 707s get? I plan on turning both PIT and MCO into European gateways, with some flights to the Caribbean and Latin America out of MCO. I will look to another market, perhaps IAH for some South American routes. I don't think I'll be getting to Asia this round...