Never do 1-freq TATL flights.
I guess it really depends on the distance of the flight. In public worlds (such as public world 506, in which I operate out of BOS, EWR, PHL and a few other major North American airports), almost everyone who flies from these places to major European airports such as LHR and CDG do a 1-frequency, apparently because of the close proximity of these airports to Europe - I mean, just over 3000nm is really not that much longer than a North American transcontinental flight. As a result, they drive prices down a great deal and my routes end up being far less profitable than they used to be - none of them make over $100,000 as of now - even though I insist on doing a 0.5-freq on these routes.
On the other hand, when you own sufficient funds you can order more airplanes and turn the 0.5-freq TATLs into daily flights. In this way, the average profit per aircraft drops, while the net profit should probably increase.
It appears to be harder to find a suitable aircraft for long-haul flights in a modern world. The range of the A319 is too short and cannot even do ATL - CDG (not to mention the A320, which cannot do anything beyond LHR/LGW - JFK/EWR), while the capacity of the A319LR is too small (the capacity offered by an A319LR on a 1-freq is less than that offered by a B752 or B762ER on a 0.5-freq). I'm thinking of the following aircraft line-up for my TATLs in a reasonably competitive private world that I'm in; what do you guys think?
$350,000 airport - $350,000 airport: B762ER 0.5-freq
$350,000 airport - $300,000 airport: B762ER 0.5-freq (with the exception of a few JFK routes that use the A319 or A319LR on 1-freq because of proximity and ease of scheduling)
$300,000 airport - $300,000 airport: B762ER 0.5-freq (depending on actual pax number)
$350,000 airport - $250,000 airport: A319LR 0.5-freq