The only reason VS is still around is due to Branson's very deep pockets.
Virgin makes a profit, and has done sso for most of it's existance. Branson invested a lot in the airline during upstart, but they certainly don't excist today because of Bransons deep pockets.
The only real airline I can think of that have made just long-haul operations work was PanAm
Singapore Airlines, Emirates, Cathay Pacific, V Australia, Cargolux, Qantas (in the 70s and 80s), Air Tahiti Nui, Sri Lankan, Air Mauritius, Air Transat, Air Caraibes, Air Greenland, World Airways, Air Austral, Air Seychelles and Biman Bangladesh.
To some extent, Qatar Airways, Etihad, Kuwait Airways and Gulf Air should also be included. They operate A32X, but most of them on medium range routes.
By comparison, Pan Am operated most of it's flights on domestic routes within the US with a massive fleet of 100 Boeing 727s, 5 737s, 12 A300s and 19 A310s. They only had 25 747s. They even operated a fleet of ATRs and Dash-7s, and had orders for 50 A320s. Pan Am wasn't a long haul-only airline, not even by a stretch.